Just as the local Chamber supports a gigantic tax-and-spend boondoggle of a "Third Bridge" -- a project that would absolutely hammer the finances of most of its members -- the national Chamber is a top-down centralized, totalitarian entity that dictates positions on issues instead of reflecting the interests of its members.
http://www.commondreams.org/news/2016/04/04/revealed-chamber-commerce-strategy-kill-empathy-its-members